バイオ材料システム工学　吉田・秋元研究室

Original papers

2021
1. “Autonomous nano-scale chemomechanical oscillation on the self-oscillating polymer brush surface by precise control of graft density”
   K. Homma, Y. Ohta, K. Minami, G. Yoshikawa, K. Nagase, A. M. Akimoto, R. Yoshida
   Langmuir, 37, 4380-4386 (2021)
2. “Selective capture and noninvasive release of cells using a thermoresponsive polymer brush with affinity peptides”
   K. Nagase, M. Shimura, R. Shimane, K. Hanaya, S. Yamada, A. M. Akimoto, T. Sugai, H. Kanazawa
   Biomater. Sci., 9, 663-674 (2021).
2020
3. “Thermoresponsive cationic block copolymer brushes for temperature- modulated stem cell separation”
   K. Nagase, A. Ohta, T. Hirotani, S. Yamada, A. M. Akimoto, H. Kanazawa
   Macromol. Rapid Commun., 2000308 (2020).
4. “Design of two complementary copolymers work as a glue for cell-laden collagen gels”
   T. Nishimoto, K. Matsukawa, K. Nagase, H. Kanazawa, A. M. Akimoto, R. Yoshida
   ChemComm, 56, 10545-10548 (2020).
5. “Antibody drug separation using thermoresponsive anionic polymer brush modified beads with optimised electrostatic and hydrophobic interactions”
   K. Nagase, S. Ishii, K. Ikeda, S. Yamada, D. Ichikawa, A. M. Akimoto, Y. Hattori, H. Kanazawa
   Sci. Rep., 10, 11896 (2020).
6. “Fabrication of self-oscillating micelles with a built-in oxidizing agent”
   T. Yoshizawa, M. Onoda, T. Ueki, R. Tamate, A. M. Akimoto, R. Yoshida
   Angew. Chem. Int. Ed., Angew. Chem. Int. Ed.,
7. “Thermoresponsive anionic copolymer brush-grafted surfaces for cell separation”
   K. Nagase, N. Uchikawa, T. Hirotani, A. M. Akimoto, H. Kanazawa
   Colloids Surf. B: Biointerfaces, 185, 110565- (2020).
8. “Mixed polymer brush as a functional ligand of silica beads for temperature-modulated hydrophobic and electrostatic interactions”
   K. Nagase, S. Kitazawa, S. Yamada, A. M. Akimoto, H. Kanazawa
   Anal. Chim. Acta, 1095, 1-13 (2020).
2019
9. “Crosslinked poly(N-isopropylacrylamide) based microfibers as cell manipulation materials with prompt cell detachment”
   T. Konishi, A. M. Akimoto, T. Nishimoto, Y. Tokura, M. Tenjimbayashi, K. Homma, K. Matsukawa, T. Kaku, Y. Hiruta, K. Nagase, H. Kanazawa, S. Shiratori
   Macromol. Rapid Commun., 40, 1900464 (2019).
10. “Reactivity control of polymer functional groups by altering the structure of thermoresponsive triblock copolymers”
    J. Akimoto, R. Tamate, S. Okazawa, A. M. Akimoto, M. Onoda, R. Yoshida, Y. Ito
    ACS Omega, 4, 16344-16351 (2019).
11. “Stable, prolonged oscillation realized through preparation of a Self-Oscillating Polymer Brush on a porous glass substrate”
    K. Homma, T. Masuda, A. M. Akimoto, K. Nagase, T. Okano, R. Yoshida
    Langmuir, 35, 9794-9801 (2019).
12. “Temperature-modulated cell-retaining column using temperature-responsive cationic copolymer hydrogel-modified silica beads”
    K. Nagase, D. Inanaga, D. Ichikawa, A. M. Akimoto, Y. Hattori, H. Kanazawa
    Colloids Surf. B: Biointerfaces, 178, 253-262 (2019).
13. “Adsorption-desorption control of fibronectin in real time at the liquid/polymer interface on a quartz crystal microbalance by thermoresponsivity”
    L. Jiatu, T. Kaku, Y. Tokura, K. Matsukawa, K. Homma, T. Nishimoto, Y. Hiruta, A. M. Akimoto, K. Nagase, H. Kanazawa, S. Shiratori
    Biomacromolecules, 20, 1748-1755 (2019).
2018
14. “Reversible and directional control of chemical wave propagation in a hydrogel by magnetic migration through liquid interfaces”
    E. Lee, Y. Kim, A. M. Akimoto, R. Yoshida
    Chem. Mater., 2000308 (2020).
15. “Precisely tunable sol-gel transition temperature by blending thermoresponsive ABC triblock terpolymers”
    M. Onoda, T. Ueki, R. Tamate, A. M. Akimoto, C. C. Hall, T. P. Lodge, R. Yoshida
    ACS Macro Lett., 7, 950-955 (2018).
    
16. “Mesenchymal stem cell culture on poly(N-isopropylacrylamide) hydrogel with repeated thermo-stimulation”
    A. M. Akimoto, E. Hasuike (co-first), K. Nagase, T. Okano, H. Kanazawa, R. Yoshida
    Int. J. Mol. Sci., 19, 1253 (2018).
17. “Macroscopic adhesion of thermoreversible ABC triblock copolymer-based hydrogels via boronic acid-sugar complexion”
    R. Tamate, K. Takahashi, T. Ueki, A. M. Akimoto, R. Yoshida
    Macromol. Rapid Commun., 39, 1700835 (2018).
18. “Photocurable ABA triblock copolymer-based ion gels utilizing photodimerization of coumarin”
    R. Tamate, T. Ueki, A. M. Akimoto, R. Yoshida, T. Oyama, H. Kokubo, M. Watanabe
    RSC Adv., 8, 3418-3422 (2018).
19. “Aspects of the Belousov-Zhabotinsky reaction inside the self-oscillating polymer brush”
    T. Masuda, A. M. Akimoto, M. Furusawa, R. Tamate, K. Nagase, T. Okano, R. Yoshida
    Langmuir, 34, 1673-1680 (2018).
2017
20. “Thermoresponsive surface-grafted gels: Controlling the "bulk" volume change properties by "surface" localized polymer grafting with various densities”
    K. Matsukawa, T. Masuda, Y. Kim, A. M. Akimoto, R. Yoshida
    Langmuir, 33, 13828-13833 (2017).
21. “Dynamic electrical behavior of thermoresponsive polymer in well-defined poly(Nisopropylacrylamide)-grafted semiconductor device”
    T. Masuda, T. Kajisa, A. M. Akimoto, A. Fujita, K. Nagase, T. Okano, T. Sakata, R. Yoshida
    RSC Adv., 7, 34517-34521 (2017).
22. “Design of a tunable self-oscillating polymer with ureido and Ru(bpy)3 moieties”
    T. Masuda, N. Shimada, T. Sasaki, A. Maruyama, A. M. Akimoto, R. Yoshida
    Angew. Chem. Int. Ed., 56, 9459-9462 (2017).
23. “Reversible conformational changes in parallel type G-quadruplex structure inside a thermoresponsive hydrogel”
    E. Hasuike, A. M. Akimoto (co-first), R. Kuroda, K. Matsukawa, Y. Hiruta, H. Kanazawa, R. Yoshida
    ChemComm, 53, 3142-3144 (2017).
24. “Fabrication of micropatterned self-oscillating polymer brush for direction control of chemical waves”
    K. Homma, T. Masuda, A. M. Akimoto, K. Nagase, K. Itoga, T. Okano, R. Yoshida
    Small, 1700041 (2017). (Highlighted in Advanced Science News)
25. “Self-assembly of thermo-responsive hydrogels via molecular recognition toward a spatially organized coculture system”
    R. Tamate, K. Takahashi, T. Ueki, A. M. Akimoto, R. Yoshida
    Biomacromolecules, 18, 281-287 (2017).
26. “Recent developments of self-oscillating polymeric systems as smart materials: from polymers to bulk hydrogels”
    Y. Kim, R. Tamate, A. M. Akimoto, R. Yoshida
    Mater. Horiz., 4, 38-54 (2017).
2016
27. “Photo-dimerization induced dynamic viscoelastic changes of ABA triblock copolymer based hydrogels for 3D cell culture”
    R. Tamate, T. Ueki, Y. Kitazawa, M. Kuzunoki, M. Watanabe, A. M. Akimoto, R. Yoshida
    Chem. Mater., 28, 6401-6408 (2016).
28. “Artificial cilia as autonomous nanoactuators: design of a gradient self-oscillating polymer brush with controlled unidirectional motion”
    T. Masuda, A. M. Akimoto, K. Nagase, T. Okano, R. Yoshida
    Macromol. Rapid Commun., e1600902 (2016).
29. “Design of tetra arm PEG-crosslinked thermoresponsive hydrogel for 3D cell culture”
    A. M. Akimoto, E. Hasuike (co-first), H. Tada, K. Nagase, T. Okano, H. Kanazawa, R. Yoshida
    Anal. Sci., 32, 1203-1205 (2016) (selected as a hot paper).
30. “A surface-grafted thermoresponsive hydrogel in which the surface structure dominates the bulk properties”
    K. Matsukawa, T. Masuda, A. M. Akimoto, R. Yoshida
    Chem Comm, 2, 11064-11067 (2016) (highlighted as a back cover).
31. “Recent advances of self-oscillating polymeric materials”
    R. Tamate, A. M. Akimoto, R. Yoshida
    Chem. Rec., 16, 1852-1867 (2016).
2015
32. “Design of self-oscillating polymer brushes and control of the dynamic behaviors”
    T. Masuda, A. M. Akimoto, K. Nagase, T. Okano, R. Yoshida
    Chem. Mater., 27, 7395-7402 (2015).
33. “Control of swelling-deswelling behavior of self-oscillating gel by designing the chemical structure”
    T. Masuda, A. Terasaki, A. M. Akimoto, K. Nagase, T. Okano, R. Yoshida
    RSC Adv.,RSC Adv., 5, 5781-5787 (2015).
2014
34. “Autonomous pulsatile flow by peristaltic motion of tubular self-oscillating gels”
    Y. Shiraki, A. M. Akimoto, T. Miyata, R. Yoshida
    Chem. Mater., 26, 5441-5443 (2014).
2013
35. “Self-oscillating polymer brushes”
    T. Masuda, M. Hidaka, Y. Murase, A. M. Akimoto, K. Nagase, T. Okano, R. Yoshida
    Angew. Chem. Int. Ed. 52, 7468-7471 (2013).
36. “Preparation of cell-culturing glass surfaces that release branched polyethyleneimine triggered by thiol-disulfide exchange”
    A. M. Akimoto, T. Takarada, M. Maeda
    Colloids Surf. B: Biointerfaces, 103, 360-365 (2013).
2011
37. “Effect of reaction solvent on the preparation of thermo-responsive stationary phase through a surface initiated atom transfer radical polymerization”
    K. Nagase, A. M. Akimoto, J. Kobayashi, A. Kikuchi, Y. Akiyama, H. Kanazawa, T. Okano
    J. Chromatogr. A, 1218, 8617-8628 (2011).
2010
38. “Preparation of thermo-responsive polymer brushes on hydrophilic polymeric beads by surface-initiated atom transfer radical polymerization for a highly resolutive separation of peptides”
    A. Mizutani, K. Nagase, A. Kikuchi, H. Kanazawa, Y. Akiyama, J. Kobayashi, M. Annaka, T. Okano
    J. Chromatogr. A, 1217, 5978-5985 (2010).
39. “Effective separation of peptides using highly dense thermo-responsive polymer brush grafted porous polystyrene beads”
    A. Mizutani, K. Nagase, A. Kikuchi, H. Kanazawa, Y. Akiyama, J. Kobayashi, M. Annaka, T. Okano
    J. Chromatogr. B, 878, 2191-2198 (2010).
40. “Thermo-responsive polymer brush-grafted porous polystyrene beads for all-aqueous chromatography”
    A. Mizutani, K. Nagase, A. Kikuchi, H. Kanazawa, Y. Akiyama, J. Kobayashi, M. Annaka, T. Okano
    J. Chromatogr. A, 1217, 522-529 (2010).
2008
41. “Aqueous chromatographic system for separation of biomolecules using thermoresponsive polymer modified stationary phase”
    H. Kanazawa, M. Nishikawa, A. Mizutani, C. Sakamoto, Y. M. Murase, Y. Nagata, A. Kikuchi, T. Okano
    J. Chromatogr. A, 1191, 157-161 (2008).
42. “Preparation of thermoresponsive polymer brush surfaces and their interaction with cells”
    A. Mizutani, A. Kikuchi, M. Yamato, H. Kanazawa, T. Okano
    Biomaterials, 29, 2073-2081 (2008).

Grants

1. JST A-STEP, 産学共同(育成型), 研究責任者 (2020-2022)
2. 第13回資生堂女性研究者サイエンスグラント (2020)
3. 民間企業との共同研究 (2018-2020)
4. 公益財団法人精密測定技術振興財団 助成事業 (2018)
5. JST 先端計測, 要素技術タイプ, チームリーダー (2016-2019)
   
   など

Awards

1. 第13回 資生堂女性研究者サイエンスグラント (2020)
2. インテリジェント材料・システムシンポジウム 高木賞 (2017)
3. Hot Paper Award, Analytical Sciences (2016)
4. 高分子学会関西支部 エクセレントポスター賞 (2009)
5. 日本分析化学会 若手優秀賞 (2008)
6. 日本薬学会物理系薬学部会 奨励賞 (2008)
7. ライフサポート学会 奨励賞 (2007)